Jon Stewart and Bill O’Reilly are set to debate a host of issues when the Comedy Central star sits down for a face-to-face interview with the Fox News icon on Wednesday.

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Stewart agreed to appear on “The O’Reilly Factor” during a two-part interview that will air tonight and Thursday. Stewart, who regularly lampoons O’Reilly and Fox News, has only appeared on the show once before — in September 2004, when he mocked O’Reilly for calling for a boycott of France. O’Reilly has appeared three times on Stewart’s “The Daily Show,” where he once called the show’s fans “stoned slackers.”

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Fox says the two talk show hosts will sit down for a taped interview that will cover everything from President Obama and health care to upcoming elections and bias in the media, according to the L.A. Times.